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F1 Report

/Users/agenda/Desktop/genome_Breon_Johnson_Full_20140714083307.txt
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/Users/agenda/Downloads/genome_Daniel_Grams_Full_20140714083206.txt
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Magnitude: 2.5
Frequency: 8.8%
References:37
Probability:25%
CYP1A2 slow caffeine metabolizer. More strongly affected by drinking coffee, because caffeine is broken down slower in your liver. Supposedly this increases risk of heart attacks, although other studies show caffeine is generally good for your heart. This also makes caffeine more effective at preventing Breast Cancer, Alzheimer's Disease, and Parkinson's disease. But too much caffeine will shrink your breasts.
Magnitude: 2.1
Frequency: 11.5%
References:62
Probability:50%
CYP2C9*3 carrier; average 40% reduction in warfarin metabolism
Magnitude: 2.1
Frequency: 72.1%
References:8
Probability:50%
blond hair & blue eyes is 4x more likely
Magnitude: 2.1
Frequency: 44.6%
References:6
ambig
Probability:50%
warfarin sensitivity (~2.5 mg/day)
Magnitude: 2
Frequency: 1.8%
References:17
Probability:25%
~4x higher risk for hyperuracemia
Magnitude: 2
Frequency: 8.3%
References:18
Probability:25%
1.6x risk
Magnitude: 2
Frequency: 15.2%
References:11
Probability:25%
rs3738401(A;A) and rs751229(G;G) together indicate homozygosity for the HEP3 haplotype of DISC1.
Magnitude: 2
Frequency: 18.6%
References:1
Probability:25%
curlier hair
Magnitude: 2
Frequency: 20.4%
Repute:bad
References:23
Probability:25%
Increased risk of Nicotine dependence among males
Magnitude: 2
Frequency: 21.2%
References:6
Probability:50%
~10% less likely to respond to citalopram
Magnitude: 2
Frequency: 22.1%
References:0
Probability:25%
Late riser. Wakes up 1 hour later than those with AA genotype. Research also suggests, then you while most people are more likely to die shortly before 11am, you are more likely to die later in the day. http://www.theatlantic.com/health/archive/2012/11/you-are-most-likely-to-die-at-11-am/265427/
Magnitude: 2
Frequency: 24.8%
References:1
Probability:25%
straighter hair
Magnitude: 2
Frequency: 28.3%
References:0
Probability:25%
Early riser. Wakes up 1 hour earlier than those with GG genotype. Research also suggests, then you are also more likely to die on a morning, shortly before 11am. http://www.theatlantic.com/health/archive/2012/11/you-are-most-likely-to-die-at-11-am/265427/
Magnitude: 2
Frequency: 29.2%
References:11
Probability:50%
Magnitude: 2
Frequency: 30.1%
References:17
Lower HDL cholesterol in women and late-onset Type-2 diabetes
Magnitude: 2
Frequency: 33.6%
References:4
Probability:50%
2.90 ng/mL lower Vitamin B6 blood concentration
Magnitude: 2
Frequency: 40.7%
References:28
Probability:25%
Shorter QT interval
Magnitude: 2
Frequency: 42.5%
References:3
Probability:50%
increased risk of coronary heart disease; better response to statins
Magnitude: 2
Frequency: 44.2%
References:2
Probability:50%
more likely to be able to smell asparagus metabolites in urine 1.67x more likely than people with (G;G) to be able to smell the methanethiol produced after eating asparagus.
Magnitude: 2
Frequency: 46.8%
References:5
Probability:25%
Normal genotype. slightly higher odds of cannabis dependence
Magnitude: 2
Frequency: 53.1%
References:8
Probability:25%
lower HDL cholesterol
Magnitude: 2
Frequency: 53.1%
References:37
Probability:25%
Fast Caffeine Metabolizer. Like the majority of people, caffeine is broken down faster in your liver, so it has less effect on you. Supposedly this decreases heart attack risk, although other studies show caffeine is generally good for the heart. Caffeine will be less effective at preventing Breast Cancer, Alzheimer's Disease, and Parkinson's disease. Caffeine will not make your breasts smaller.
Magnitude: 2
Frequency: 60.2%
References:13
Probability:25%
~4x higher risk for hyperuracemia
Magnitude: 2
Frequency: 61.9%
References:32
Probability:25%
blue eye color, 99% of the time
Magnitude: 2
References:6
Probability:25%
increased susceptibility to novelty seeking
Magnitude: 2
References:10
Probability:25%
frontal brain having to working harder during a working memory task. higher scores of neuroticism and lower scores of conscientiousness hyperactivations in areas associated with elaborate episodic memory encoding and retrieval strategies.
Magnitude: 2
Frequency: 15.6%
References:4
ambig
Probability:50%
1.6x risk for ARMD slightly increased risk of ARMD but if also rs380390(C;C) the risk is greatly increased, this should be automatically detected by gs134
Magnitude: 2
References:5
ambig
Probability:25%
Homozygous for CYP2D6 variants (non-CYP2D6*1)
Magnitude: 1.8
Frequency: 53.6%
References:6
Normal risk of Basal Cell Carcinoma. Normal risk for this kind of skin cancer.
Magnitude: 1.8
Frequency: 54.9%
References:25
Probability:50%
Normal risk for Childhood Asthma.
Magnitude: 1.6
Frequency: 24.1%
References:6
Probability:50%
1.6x increased risk for preeclampsia in most populations Note: this is relevant to the fetal genotype, not the maternal genotype
Magnitude: 1.6
References:2
1.6x increased risk for breast cancer in females over 60
Magnitude: 1.5
Frequency: 5.3%
References:20
Probability:25%
Sex Hormone-Binding Globulin levels are 0.4 standard deviations higher
Magnitude: 1.5
Frequency: 18.6%
References:1
Probability:25%
more able to detect β-ionone (floral) fragrance
Magnitude: 1.5
Frequency: 18.8%
References:35
Probability:25%
ex-smokers at 2x higher risk for COPD; supplement with Vitamin D?
Magnitude: 1.5
Frequency: 28.3%
References:1
Probability:50%
increased risk of schizophrenia in limited study
Magnitude: 1.5
Frequency: 41.6%
References:1
Probability:25%
less able to detect β-ionone (floral) fragrance
Magnitude: 1.5
Frequency: 45.1%
References:91
Probability:50%
Minorly increased risk of mental illness and osteoarthritis
Magnitude: 1.5
References:0
Probability:50%
One copy of CYP2A6*5 non-functioning variant; impaired nicotine metabolism
Magnitude: 1.4
References:7
Probability:50%
some resistance to tuberculosis some resistance to tuberculosis
Magnitude: 1.3
Frequency: 45.1%
References:0
1.3x higher risk for schizophrenia (among Han Chinese)
Magnitude: 1.3
Frequency: 46.9%
References:63
Probability:50%
1.3x increased risk that pediatric inhaler use may make asthma worse
Magnitude: 1.25
Frequency: 55.8%
References:0
Probability:50%
Very common. Normal risk of Parkinson's disease. Approximately 55% of non-asian people have this genotype which is associated with slightly higher risk of Parkinson's disease when compared to genotype (G;G). It is notable because it is the first SNP patented by 23andMe rs10513789(T) increased risk of developing Parkinson's Disease GenomicsLawReport
Magnitude: 1.2
Frequency: 13.3%
References:4
Probability:50%
1.2x increased risk for ovarian cancer
Magnitude: 1.2
Frequency: 15.9%
References:2
Probability:25%
For type-1 diabetics, 1.6x increased nephropathy risk
Magnitude: 1.2
Frequency: 19.5%
References:7
Probability:25%
1.2x higher risk for migraines
Magnitude: 1.2
Frequency: 30.8%
References:16
Probability:50%
1.5x reduced risk of multiple multiple myeloma omim
Magnitude: 1.1
Frequency: 4.4%
References:8
Probability:25%
Increased extra-pyramidal symptom risk as a result of risperidone treatment in a study of 321 psychiatric inpatients. Possibly less 'Insistence on Sameness' in ADI-R test.
Magnitude: 1.1
Frequency: 10.6%
References:6
Probability:25%
risk genotype
Magnitude: 1.1
Frequency: 45.1%
References:79
complex! see rs4880
Magnitude: 1.1
Frequency: 46.0%
References:2
The (A;G) genotype averages 2.8 PIQ points higher than the (G;G), but averages 2.84 PIQ points lower than (A;A) genotype
Magnitude: 1
Frequency: 19.5%
References:0
Probability:50%
mixed homo-sapiens (human) and Neanderthal
Magnitude: 1
Frequency: 20.4%
References:1
ancestral Neanderthal allele (heterozygote)
Magnitude: 1
Frequency: 37.2%
References:5
Probability:50%
Higher serum levels of vitamin D
Magnitude: 1
Frequency: 45.1%
References:11
Probability:50%
Magnitude: 1
Frequency: 67.3%
References:8
Probability:25%
Possibly more 'Insistence on Sameness' on ADI-R test.Possibly increased FTND nicotine dependence.[http://www.ncbi.nlm.nih.gov/pubmed/22309839?dopt=Abstract
Magnitude: 1
Frequency: 70.3%
References:1
Probability:50%
normal risk of autism
Magnitude: 1
Frequency: 78.8%
References:10
Probability:50%
freckles more likely
Magnitude: 1
Frequency: 92.9%
References:1
Probability:50%
Conduct disorder (CD) is one of the most prevalent childhood psychiatric conditions, and is associated with a number of serious concomitant and future problems. CD symptomatology is known to have a considerable genetic component, with heritability estimates in the range of 50%. Four SNPs reached genome-wide significance with CD symptom count, based on P < 5x10^-8 Two of these SNPs (rs16891867 and rs1861046) were in the gene C1QTNF7 (C1q and tumor necrosis factor-related protein 7). These SNPs were in high LD (r^2=0.97). The other top two SNPs meeting genome-wide significance were intergenic and located on chromosomes 11 and 13. Alleles A/G were found to be associated with CD symptom count or CD case status. [http://www.downstate.edu/hbnl/documents/2010-Dick-Genome-wideassociationstudyof...
Magnitude: 1
References:13
Probability:50%
increased creativity? Associated with creativity (or at least people who answer ads asking for people who believe they have high creativity) in people with high intellectual and academic performance. Intriguingly, the highest creative achievements and creative-thinking scores were found in people who carried the (T;T) genotype, which was previously shown to be related to psychosis risk and altered prefrontal activation. omim rs6994992 in 5-prime promoter region of the NRG1 gene regulates expression of the NRG1 type IV isoform. The T allele, which is the schizophrenia risk allele, showed a 65% increase in promoter activity. newscientist reports that this variation has been linked to psychosis, poor memory and sensitivity to criticism. About 50 per cent of healthy Europeans have one copy of...
Magnitude: 1
References:64
Probability:50%
Magnitude: 1
Frequency: 19.0%
References:4
ambig
Probability:50%
Reduced conversion of beta-carotene to retinol Associated with Rs7501331 and reduced BCMO1, lower ability to convert beta-carotene to retinyl esters and higher serum beta-carotene levels. See also Rs7501331


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